compensation, genetic mutations, or stress responses

Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses

Background: The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, leading to concerted efforts to study how the network responds to various proteotoxic stresses. This is often accomplished using ectopic overexpression of well-characterized, model misfolded protein substrates.
However, how cells tolerate large-scale, diverse burden to the proteostasis network is not understood. Aneuploidy, the state of imbalanced chromosome content, adversely affects the proteostasis network by dysregulating the expression of hundreds of proteins simultaneously. Using aneuploid haploid yeast cells as a model, we address whether cells can tolerate large-scale, diverse challenges to the proteostasis network.
Results: Here we characterize several aneuploid Saccharomyces cerevisiae strains isolated from a collection of stable, randomly generated yeast aneuploid cells. These strains exhibit robust growth and resistance to multiple drugs which induce various forms of proteotoxic stress.
Whole genome re-sequencing of the strains revealed this was not the result of genetic mutations, and transcriptome profiling combined with ribosome footprinting showed that genes are expressed and translated in accordance to chromosome copy number. In some strains, various facets of the proteostasis network are mildly upregulated without chronic activation of environmental stress response or heat shock response pathways.
No severe defects were observed in the degradation of misfolded proteins, using model misfolded substrates of endoplasmic reticulum-associated degradation or cytosolic quality control pathways, and protein biosynthesis capacity was not impaired.
Conclusions: We show that yeast strains of some karyotypes in the genetic background studied here can tolerate the large aneuploidy-associated burden to the proteostasis machinery without genetic changes, dosage compensation, or activation of canonical stress response pathways.
We suggest that proteotoxic stress, while common, is not always an obligate consequence of aneuploidy, but rather certain karyotypes and genetic backgrounds may be able to tolerate the excess protein burden placed on the protein homeostasis machinery. This may help clarify how cancer cells are paradoxically both highly aneuploid and highly proliferative at the same time.
informedchoiceaboutcancerscreening
informedchoiceaboutcancerscreening

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E3 ubiquitin protein ligase CHIP ELISA kit

E01A13116 96T
EUR 700
Description: ELISA

Chicken E3 ubiquitin protein ligase CHIP ELISA kit

E01A91611 96T
EUR 700
Description: ELISA

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

AP74853 1mg
EUR 3209

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

C115-10ug 10ug
EUR 187.2
Description: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

C115-1mg 1mg
EUR 2739.6
Description: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

C115-500ug 500ug
EUR 1935.6
Description: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

C115-50ug 50ug
EUR 442.8
Description: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E01A48025 96T
EUR 700
Description: ELISA

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep E3 ubiquitin protein ligase CHIP ELISA kit

E01A100318 96T
EUR 700
Description: ELISA

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01A4352 96T
EUR 700
Description: ELISA

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E01A21856 96T
EUR 700
Description: ELISA

Canine E3 ubiquitin protein ligase CHIP ELISA kit

E01A65457 96T
EUR 700
Description: ELISA

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E01A30593 96T
EUR 700
Description: ELISA

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E01A74172 96T
EUR 700
Description: ELISA

Bovine E3 ubiquitin protein ligase CHIP ELISA kit

E01A82890 96T
EUR 700
Description: ELISA

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Porcine E3 ubiquitin protein ligase CHIP ELISA kit

E01A56743 96T
EUR 700
Description: ELISA

Guinea Pig E3 ubiquitin protein ligase CHIP ELISA kit

E01A39306 96T
EUR 700
Description: ELISA

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Copper, chip

09434-15 500G
EUR 46.9

Human E3 ubiquitin- protein ligase CHIP, STUB1 ELISA KIT

ELI-50737h 96 Tests
EUR 988.8

Carboxy Terminus of Hsp70-Interacting Protein (CHIP) Antibody

20-abx142251
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 50 ul

CHIP Peptide

45-398P 0.1 mg
EUR 405.6
Description: STUB1 / CHIP Peptide

EpiQuik Methyl-CpG Binding Domain Protein 2 ChIP Kit 

P-2017
  • Ask for price
  • Ask for price
  • Ask for price
  • 48 Reactions
  • 24 Reactions
  • 48 Reactions

Aluminium, chip

01701-45 500G
EUR 80.5

Aluminium, chip

01701-74 100G
EUR 25.9

DiagAg™ Protein G Agarose Particles Enzymatic ChIP Kit

DAG-CS23-04 1 Kit
EUR 1280

EpiQuik Tissue Methyl-CpG Binding Domain Protein 2 ChIP Kit

P-2018 48 Reactions
EUR 1067.46

DiagAg™ Plus Protein G Agarose Particles Enzymatic ChIP Kit

DAG-CS23-03 1 Kit
EUR 1390

Human CHIP Antibody

32585-05111 150 ug
EUR 215

STUB1/CHIP Antibody

DF6303 200ul
EUR 420

STUB1/CHIP Antibody

DF6303-100ul 100ul
EUR 280

STUB1/CHIP Antibody

DF6303-200ul 200ul
EUR 350

STUB1/CHIP Antibody

AF6514 100ul
EUR 420

STUB1/CHIP Antibody

AF6514-100ul 100ul
EUR 280

STUB1/CHIP Antibody

AF6514-200ul 200ul
EUR 350

CHIP (Human) - Antibody

H-CHIP-01 100 μl
EUR 469.8

ChIP Swelling Buffer

10450057-1 100 mL
EUR 34.32

ChIP Swelling Buffer

10450057-2 250 mL
EUR 54.54

ChIP Dilution Buffer

22050032-1 25 mL Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

ChIP Dilution Buffer

22050032-2 50 mL Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

ChIP Sonication Buffer

10450059-1 100 ml
EUR 34.32

ChIP Sonication Buffer

10450059-2 250 ml
EUR 54.54

Nucleosome ChIP Buffer

10450074-1 50 ml
EUR 44.47

Nucleosome ChIP Buffer

10450074-2 100 ml
EUR 73.01

CHIP, human recombinant

4898-25 each
EUR 418.8

E3 ubiquitin-protein ligase CHIP

AP79345 1mg
EUR 2640

CHIP Polyclonal Antibody

E11-202355 100ug/100ul
EUR 225
Description: Available in various conjugation types.

CHIP Polyclonal Antibody

ABP58142-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

ABP58142-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

ABP58142-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

E44H09962 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

ChIP Wash Buffer A

10450060-1 100 ml
EUR 34.32

ChIP Wash Buffer A

10450060-2 250 ml
EUR 54.54

ChIP Wash Buffer B

10450061-1 100 ml
EUR 34.32

ChIP Wash Buffer B

10450061-2 250 ml
EUR 54.54

EpiQuik P ChIP Kit 

P-2014B 24 Reactions
EUR 592

ChIP Lysis Buffer III

10450058-1 100 mL
EUR 36.85

ChIP Lysis Buffer III

10450058-2 250 ml
EUR 54.54

ChIP SDS Lysis Buffer

22050031-1 10 mL Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

ChIP SDS Lysis Buffer

22050031-2 25 mL Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

LiCl ChIP Wash Buffer

22050035-1 25 mL
EUR 49.01

LiCl ChIP Wash Buffer

22050035-2 50 mL
EUR 69.96

EpiQuik Plant ChIP Kit 

P-2014
  • Ask for price
  • Ask for price
  • Ask for price
  • 48 Reactions
  • 24 Reactions
  • 48 Reactions

ChIP Dilution Buffer - I

10450063-1 100 ml
EUR 34.4

ChIP Dilution Buffer - I

10450063-2 250 ml
EUR 54.64

ChIP Dilution Buffer - II

10450064-1 100 ml
EUR 34.4

ChIP Dilution Buffer - II

10450064-2 250 ml
EUR 54.64

BRCA1 Antibody (ChIP grade)

GWB-6B3E8D 0.1 mg Ask for price

Anti-STUB1 / CHIP antibody

STJ70128 100 µg
EUR 430.8

ChIP Extraction Solution I

10450068-1 100 ml
EUR 34.4

ChIP Extraction Solution I

10450068-2 250 ml
EUR 54.64

ChIP Extraction Solution II

10450069-1 100 ml
EUR 34.4

ChIP Extraction Solution II

10450069-2 250 ml
EUR 54.64

Polyclonal STUB1 / CHIP Antibody

AMM08034G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human STUB1 / CHIP . This antibody is tested and proven to work in the following applications:

CHIP Rabbit Polyclonal Antibody

ES11301-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against CHIP from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

CHIP Rabbit Polyclonal Antibody

ES11301-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against CHIP from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Nucleosome ChIP Sonication Buffer

10450076-1 100 ml
EUR 34.4

Nucleosome ChIP Sonication Buffer

10450076-2 250 ml
EUR 54.64

Quantitative genetic architecture of adaptive phenology traits in the deciduous tree, Populus trichocarpa (Torr. and Gray)

In a warming climate, the ability to accurately predict and track shifting environmental conditions will be fundamental for plant survival. Environmental cues define the transitions between growth and dormancy as plants synchronise development with favourable environmental conditions, however these cues are predicted to change under future climate projections which may have profound impacts on tree survival and growth.
Here, we use a quantitative genetic approach to estimate the genetic basis of spring and autumn phenology in Populus trichocarpa to determine this species capacity for climate adaptation. We measured bud burst, leaf coloration, and leaf senescence traits across two years (2017-2018) and combine these observations with measures of lifetime growth to determine how genetic correlations between phenology and growth may facilitate or constrain adaptation.
Timing of transitions differed between years, although we found strong cross year genetic correlations in all traits, suggesting that genotypes respond in consistent ways to seasonal cues. Spring and autumn phenology were correlated with lifetime growth, where genotypes that burst leaves early and shed them late had the highest lifetime growth.
We also identified substantial heritable variation in the timing of all phenological transitions (h2 = 0.5-0.8) and in lifetime growth (h2 = 0.8). The combination of additive variation and favourable genetic correlations in phenology traits suggests that populations of cultivated varieties of P. Trichocarpa may have the capability to adapt their phenology to climatic changes without negative impacts on growth.

Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

The gastrointestinal tract hosts the natural reservoir of microbiota since birth. The microbiota includes various bacteria that establish a progressively mutual relationship with the host. Of note, the composition of gut microbiota is rather individual-specific and, normally, depends on both the host genotype and environmental factors.
The study of the bacterial profile in the gut demonstrates that dominant and minor phyla are present in the gastrointestinal tract with bacterial density gradually increasing in oro-aboral direction. The cross-talk between bacteria and host within the gut strongly contributes to the host metabolism, to structural and protective functions. Dysbiosis can develop following aging, diseases, inflammatory status, and antibiotic therapy. Growing evidences show a possible link between the microbiota and Familial Mediterranean Fever (FMF), through a shift of the relative abundance in microbial species.
To which extent such perturbations of the microbiota are relevant in driving the phenotypic manifestations of FMF with respect to genetic background, remains to be further investigated.

Dog E3 ubiquitin protein ligase CHIP ELISA kit

E08E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Canine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E3 ubiquitin protein ligase CHIP ELISA kit

E08E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Canine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E3 ubiquitin protein ligase CHIP ELISA kit

E01A13116 96T
EUR 700
Description: ELISA

Chicken E3 ubiquitin protein ligase CHIP ELISA kit

E01A91611 96T
EUR 700
Description: ELISA

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

AP74853 1mg
EUR 3209

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

C115-10ug 10ug
EUR 187.2
Description: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

C115-1mg 1mg
EUR 2739.6
Description: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

C115-500ug 500ug
EUR 1935.6
Description: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human E3 Ubiquitin-Protein Ligase CHIP/CHIP

C115-50ug 50ug
EUR 442.8
Description: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E01A48025 96T
EUR 700
Description: ELISA

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Sheep E3 ubiquitin protein ligase CHIP ELISA kit

E01A100318 96T
EUR 700
Description: ELISA

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01A4352 96T
EUR 700
Description: ELISA

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E01A21856 96T
EUR 700
Description: ELISA

Canine E3 ubiquitin protein ligase CHIP ELISA kit

E01A65457 96T
EUR 700
Description: ELISA

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E01A30593 96T
EUR 700
Description: ELISA

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E01A74172 96T
EUR 700
Description: ELISA

Bovine E3 ubiquitin protein ligase CHIP ELISA kit

E01A82890 96T
EUR 700
Description: ELISA

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Porcine E3 ubiquitin protein ligase CHIP ELISA kit

E01A56743 96T
EUR 700
Description: ELISA

Guinea Pig E3 ubiquitin protein ligase CHIP ELISA kit

E01A39306 96T
EUR 700
Description: ELISA

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Copper, chip

09434-15 500G
EUR 46.9

Human E3 ubiquitin- protein ligase CHIP, STUB1 ELISA KIT

ELI-50737h 96 Tests
EUR 988.8

Carboxy Terminus of Hsp70-Interacting Protein (CHIP) Antibody

20-abx142251
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  • 100 ul
  • 200 ul
  • 50 ul

CHIP Peptide

45-398P 0.1 mg
EUR 405.6
Description: STUB1 / CHIP Peptide

EpiQuik Methyl-CpG Binding Domain Protein 2 ChIP Kit 

P-2017
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  • 48 Reactions
  • 24 Reactions
  • 48 Reactions

Aluminium, chip

01701-45 500G
EUR 80.5

Aluminium, chip

01701-74 100G
EUR 25.9

DiagAg™ Protein G Agarose Particles Enzymatic ChIP Kit

DAG-CS23-04 1 Kit
EUR 1280

EpiQuik Tissue Methyl-CpG Binding Domain Protein 2 ChIP Kit

P-2018 48 Reactions
EUR 1067.46

DiagAg™ Plus Protein G Agarose Particles Enzymatic ChIP Kit

DAG-CS23-03 1 Kit
EUR 1390

Human CHIP Antibody

32585-05111 150 ug
EUR 215

STUB1/CHIP Antibody

DF6303 200ul
EUR 420

STUB1/CHIP Antibody

DF6303-100ul 100ul
EUR 280

STUB1/CHIP Antibody

DF6303-200ul 200ul
EUR 350

STUB1/CHIP Antibody

AF6514 100ul
EUR 420

STUB1/CHIP Antibody

AF6514-100ul 100ul
EUR 280

STUB1/CHIP Antibody

AF6514-200ul 200ul
EUR 350

CHIP (Human) - Antibody

H-CHIP-01 100 μl
EUR 469.8

ChIP Swelling Buffer

10450057-1 100 mL
EUR 34.32

ChIP Swelling Buffer

10450057-2 250 mL
EUR 54.54

ChIP Dilution Buffer

22050032-1 25 mL Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

ChIP Dilution Buffer

22050032-2 50 mL Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

ChIP Sonication Buffer

10450059-1 100 ml
EUR 34.32

ChIP Sonication Buffer

10450059-2 250 ml
EUR 54.54

Nucleosome ChIP Buffer

10450074-1 50 ml
EUR 44.47

Nucleosome ChIP Buffer

10450074-2 100 ml
EUR 73.01

CHIP, human recombinant

4898-25 each
EUR 418.8

E3 ubiquitin-protein ligase CHIP

AP79345 1mg
EUR 2640

CHIP Polyclonal Antibody

E11-202355 100ug/100ul
EUR 225
Description: Available in various conjugation types.

CHIP Polyclonal Antibody

ABP58142-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

ABP58142-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

ABP58142-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

E44H09962 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

ChIP Wash Buffer A

10450060-1 100 ml
EUR 34.32

ChIP Wash Buffer A

10450060-2 250 ml
EUR 54.54

ChIP Wash Buffer B

10450061-1 100 ml
EUR 34.32

ChIP Wash Buffer B

10450061-2 250 ml
EUR 54.54

EpiQuik P ChIP Kit 

P-2014B 24 Reactions
EUR 592

ChIP Lysis Buffer III

10450058-1 100 mL
EUR 36.85

ChIP Lysis Buffer III

10450058-2 250 ml
EUR 54.54

ChIP SDS Lysis Buffer

22050031-1 10 mL Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

ChIP SDS Lysis Buffer

22050031-2 25 mL Ask for price
Description: Chromatin Immunoprecipitation (ChIP) assays

LiCl ChIP Wash Buffer

22050035-1 25 mL
EUR 49.01

LiCl ChIP Wash Buffer

22050035-2 50 mL
EUR 69.96

EpiQuik Plant ChIP Kit 

P-2014
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  • 48 Reactions
  • 24 Reactions
  • 48 Reactions

ChIP Dilution Buffer - I

10450063-1 100 ml
EUR 34.4

ChIP Dilution Buffer - I

10450063-2 250 ml
EUR 54.64

ChIP Dilution Buffer - II

10450064-1 100 ml
EUR 34.4

ChIP Dilution Buffer - II

10450064-2 250 ml
EUR 54.64

BRCA1 Antibody (ChIP grade)

GWB-6B3E8D 0.1 mg Ask for price

Anti-STUB1 / CHIP antibody

STJ70128 100 µg
EUR 430.8

ChIP Extraction Solution I

10450068-1 100 ml
EUR 34.4

ChIP Extraction Solution I

10450068-2 250 ml
EUR 54.64

ChIP Extraction Solution II

10450069-1 100 ml
EUR 34.4

ChIP Extraction Solution II

10450069-2 250 ml
EUR 54.64

Polyclonal STUB1 / CHIP Antibody

AMM08034G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human STUB1 / CHIP . This antibody is tested and proven to work in the following applications:

CHIP Rabbit Polyclonal Antibody

ES11301-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against CHIP from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

CHIP Rabbit Polyclonal Antibody

ES11301-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against CHIP from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Nucleosome ChIP Sonication Buffer

10450076-1 100 ml
EUR 34.4

Nucleosome ChIP Sonication Buffer

10450076-2 250 ml
EUR 54.64

TE Buffer for ChIP Assay

22050037-1 25 mL Ask for price

TE Buffer for ChIP Assay

22050037-2 50 mL Ask for price

Low Salt ChIP Wash Buffer

22050033-1 25 mL Ask for price

Low Salt ChIP Wash Buffer

22050033-2 50 mL Ask for price

High Salt ChIP Wash Buffer

22050034-1 25 mL
EUR 47.3

High Salt ChIP Wash Buffer

22050034-2 50 mL
EUR 68.45

Nucleosome ChIp Wash Buffer A

10450077-1 100 ml
EUR 34.4

Nucleosome ChIp Wash Buffer A

10450077-2 250 ml
EUR 54.64

ChromaFlash One-Step ChIP Kit

P-2025
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  • 96 reactions
  • 48 reactions
  • 96 reactions

Goat anti-STUB1 / CHIP Antibody

dAP-0469 50ug
EUR 264.6

CHIP (Human) - Purified IgG Antibody

G-CHIP-01 200 μg
EUR 604.8

Anti-RIP140 Antibody ChIP grade

STJ502791 100 µg
EUR 571.2

Phospho-STUB1/CHIP (Ser19) Antibody

AF3514 100ul
EUR 540

Phospho-STUB1/CHIP (Ser19) Antibody

AF3514-100ul 100ul
EUR 350

Phospho-STUB1/CHIP (Ser19) Antibody

AF3514-200ul 200ul
EUR 450

Nucleosome ChIP Sonication Buffer 2X

10450075-1 100 ml
EUR 34.4

Nucleosome ChIP Sonication Buffer 2X

10450075-2 250 ml
EUR 54.64

Human CHIP Antibody (Biotin Conjugate)

32585-05121 150 ug
EUR 315

ChromaFlash High-Sensitivity ChIP Kit  

P-2027
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  • 48 Reactions
  • 24 Reactions
  • 48 Reactions

Cell Lysis Buffer I for ChIP

10450053-1 100 ml
EUR 34.6

Cell Lysis Buffer I for ChIP

10450053-2 250 ml
EUR 54.54

Cell Lysis Buffer II for ChIP

10450054-1 100 ml
EUR 34.32

Cell Lysis Buffer II for ChIP

10450054-2 250 ml
EUR 54.54

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