compensation, genetic mutations, or stress responses

Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses

Background: The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain proteostasis is associated with aging and disease, leading to concerted efforts to study how the network responds to various proteotoxic stresses. This is often accomplished using ectopic overexpression of well-characterized, model misfolded protein substrates.
However, how cells tolerate large-scale, diverse burden to the proteostasis network is not understood. Aneuploidy, the state of imbalanced chromosome content, adversely affects the proteostasis network by dysregulating the expression of hundreds of proteins simultaneously. Using aneuploid haploid yeast cells as a model, we address whether cells can tolerate large-scale, diverse challenges to the proteostasis network.
Results: Here we characterize several aneuploid Saccharomyces cerevisiae strains isolated from a collection of stable, randomly generated yeast aneuploid cells. These strains exhibit robust growth and resistance to multiple drugs which induce various forms of proteotoxic stress.
Whole genome re-sequencing of the strains revealed this was not the result of genetic mutations, and transcriptome profiling combined with ribosome footprinting showed that genes are expressed and translated in accordance to chromosome copy number. In some strains, various facets of the proteostasis network are mildly upregulated without chronic activation of environmental stress response or heat shock response pathways.
No severe defects were observed in the degradation of misfolded proteins, using model misfolded substrates of endoplasmic reticulum-associated degradation or cytosolic quality control pathways, and protein biosynthesis capacity was not impaired.
Conclusions: We show that yeast strains of some karyotypes in the genetic background studied here can tolerate the large aneuploidy-associated burden to the proteostasis machinery without genetic changes, dosage compensation, or activation of canonical stress response pathways.
We suggest that proteotoxic stress, while common, is not always an obligate consequence of aneuploidy, but rather certain karyotypes and genetic backgrounds may be able to tolerate the excess protein burden placed on the protein homeostasis machinery. This may help clarify how cancer cells are paradoxically both highly aneuploid and highly proliferative at the same time.
informedchoiceaboutcancerscreening
informedchoiceaboutcancerscreening

Anti-CHIP antibody

STJ192459 200 µl
EUR 197
Description: Unconjugated Rabbit polyclonal to CHIP

CHIP Polyclonal Antibody

ABP58142-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

ABP58142-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

ABP58142-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP, human recombinant

4898-25
EUR 349

EpiQuik Plant ChIP Kit

P-2014 48 Reactions
EUR 788.05
Description: Ask the seller for details

Polyclonal STUB1 / CHIP Antibody

AMM08034G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human STUB1 / CHIP . This antibody is tested and proven to work in the following applications:

Anti-STUB1 / CHIP antibody

STJ70128 100 µg
EUR 359

pCMV-HA-chip Plasmid

PVTB00025-2a 2 ug
EUR 356

pcDNA3.0-Flag-CHIP Plasmid

PVTB00152-2b 2 ug
EUR 356

pcDNA3.0-EGFP-CHIP Plasmid

PVTB00152-2c 2 ug
EUR 356

pcDNA3.0-HA-CHIP Plasmid

PVTB00152-2d 2 ug
EUR 356

EpiQuik Chromatin Immunoprecipitation (ChIP) Kit

P-2002 96 Reactions
EUR 904.05
Description: Ask the seller for details

ChromaFlash One-Step ChIP Kit

P-2025 96 reactions
EUR 889.55
Description: fast delivery possible

ChromaFlash High-Sensitivity ChIP Kit

P-2027 48 Reactions
EUR 643.05
Description: Ask the seller for details

Human CHIP Antibody (Biotin Conjugate)

32585-05121 150 ug
EUR 369

Anti-RIP140 Antibody ChIP grade

STJ502791 100 µg
EUR 476

Carboxy Terminus of Hsp70-Interacting Protein (CHIP) Antibody

20-abx142251
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul

Rat E3 ubiquitin protein ligase CHIP ELISA kit

E02E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E3 ubiquitin protein ligase CHIP ELISA kit

E02E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E3 ubiquitin protein ligase CHIP ELISA kit

E02E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E3 ubiquitin protein ligase CHIP ELISA kit

E08E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E3 ubiquitin protein ligase CHIP ELISA kit

E08E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E3 ubiquitin protein ligase CHIP ELISA kit

E08E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit

P-2003 96 Reactions
EUR 904.05
Description: reagents widely cited

EpiQuik Methyl-Histone H3K4 ChIP Kit

P-2007 48 Reactions
EUR 860.55
Description: fast delivery possible

EpiQuik Acetyl-Histone H3 ChIP Kit

P-2010 48 Reactions
EUR 875.05
Description: The best epigenetics products

EpiQuik Acetyl-Histone H4 ChIP Kit

P-2011 48 Reactions
EUR 875.05
Description: kits suitable for this type of research

EpiQuik Methyl-Histone H3K27 ChIP Kit

P-2015 48 Reactions
EUR 889.55
Description: The best epigenetics products

ChromaFlash One-Step Magnetic ChIP Kit

P-2026 96 Reactions
EUR 889.55
Description: reagents widely cited

Pre-Sure ChIP Antibody Validation Kit

P-2031 96 reactions
EUR 1034.55
Description: kits suitable for this type of research

Polyclonal STUB1 / CHIP Antibody (C-Terminus)

AMM08035G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human STUB1 / CHIP (C-Terminus). This antibody is tested and proven to work in the following applications:

Human CHIP AssayLite Antibody (FITC Conjugate)

32585-05141 150 ug
EUR 428

Human CHIP AssayLite Antibody (RPE Conjugate)

32585-05151 150 ug
EUR 428

Human CHIP AssayLite Antibody (APC Conjugate)

32585-05161 150 ug
EUR 428

Human CHIP AssayLite Antibody (PerCP Conjugate)

32585-05171 150 ug
EUR 471

Polyclonal Goat Anti-STUB1 / CHIP Antibody

APR16403G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-STUB1 / CHIP . This antibody is tested and proven to work in the following applications:

Anti-Histone H2B - ChIP Grade (4G6)

YF-MA16342 100 ug
EUR 363
Description: Mouse monoclonal to Histone H2B - ChIP Grade

Human E3 ubiquitin-protein ligase CHIP(STUB1) ELISA kit

CSB-EL022887HU-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human E3 ubiquitin-protein ligase CHIP (STUB1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human E3 ubiquitin-protein ligase CHIP(STUB1) ELISA kit

1-CSB-EL022887HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human E3 ubiquitin-protein ligase CHIP(STUB1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

EpiQuik Methyl-CpG Binding Domain Protein 2 ChIP Kit

P-2017 48 Reactions
EUR 889.55
Description: fast delivery possible

Human STUB1/ E3 ubiquitin-protein ligase CHIP ELISA Kit

E2420Hu 1 Kit
EUR 571

Human STUB1(E3 ubiquitin-protein ligase CHIP) ELISA Kit

EH3833 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

ELISA kit for Human E3 ubiquitin-protein ligase CHIP

EK4512 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human E3 ubiquitin-protein ligase CHIP in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse STUB1(E3 ubiquitin-protein ligase CHIP) ELISA Kit

EM1381 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Human E3 ubiquitin- protein ligase CHIP, STUB1 ELISA KIT

ELI-50737h 96 Tests
EUR 824

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

EpiQuik Tri-Methyl-Histone H3K9 ChIP Kit

P-2006 48 Reactions
EUR 875.05
Description: kits suitable for this type of research

EpiQuik Tissue Methyl-Histone H3K9 ChIP Kit

P-2008 48 Reactions
EUR 875.05
Description: reagents widely cited

EpiQuik Tissue Methyl-Histone H3K4 ChIP Kit

P-2009 48 Reactions
EUR 875.05
Description: Ask the seller for details

EpiQuik Tissue Acetyl-Histone H3 ChIP Kit

P-2012 48 Reactions
EUR 875.05
Description: fast delivery possible

EpiQuik Tissue Acetyl-Histone H4 ChIP Kit

P-2013 48 Reactions
EUR 875.05
Description: reagents widely cited

EpiQuik Tissue Methyl-Histone H3K27 ChIP Kit

P-2016 48 Reactions
EUR 889.55
Description: kits suitable for this type of research

EpiNext ChIP-Seq High-Sensitivity Kit (Illumina)

P-2030 24 Reactions
EUR 1498.55
Description: The best epigenetics products

ELISA kit for Human STUB1 (E3 ubiquitin-protein ligase CHIP)

E-EL-H5533 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human STUB1 (E3 ubiquitin-protein ligase CHIP) in samples from Serum, Plasma, Cell supernatant

EpiQuik Tissue Methyl-CpG Binding Domain Protein 2 ChIP Kit

P-2018 48 Reactions
EUR 889.55
Description: reagents widely cited

ELISA kit for Human E3 ubiquitin-protein ligase CHIP (STUB1)

KTE60397-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase CHIP (STUB1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human E3 ubiquitin-protein ligase CHIP (STUB1)

KTE60397-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase CHIP (STUB1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human E3 ubiquitin-protein ligase CHIP (STUB1)

KTE60397-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase CHIP (STUB1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

STUB1 ELISA Kit| Mouse E3 ubiquitin-protein ligase CHIP ELISA Ki

EF013909 96 Tests
EUR 689

Rabbit IgG (non-immune, isotype control, CHIP/IP grade)

20009-1-CH 100 ug
EUR 225

Hyperactive In-Situ ChIP Library Prep Kit for Illumina (pG-Tn5)

TD901-01 12 rxn
EUR 996

Hyperactive In-Situ ChIP Library Prep Kit for Illumina (pG-Tn5)

TD901-02 48 rxn
EUR 3461

Hyperactive In-Situ ChIP Library Prep Kit for Illumina (pA-Tn5)

TD902-01 12 rxn
EUR 996

Hyperactive In-Situ ChIP Library Prep Kit for Illumina (pA-Tn5)

TD902-02 48 rxn
EUR 3461

pLDH Protein Protein

abx061407-1mg 1 mg
EUR 2639

pLDH Protein Protein

abx061408-1mg 1 mg
EUR 2639

Protein A Protein

abx061461-10mg 10 mg
EUR 439

Protein A Protein

abx069907-100mg 100 mg
EUR 467

Protein G Protein

20-abx260044
  • EUR 1970.00
  • EUR 467.00
  • EUR 230.00
  • 100 mg
  • 10 mg
  • 1 mg

Quantitative genetic architecture of adaptive phenology traits in the deciduous tree, Populus trichocarpa (Torr. and Gray)

In a warming climate, the ability to accurately predict and track shifting environmental conditions will be fundamental for plant survival. Environmental cues define the transitions between growth and dormancy as plants synchronise development with favourable environmental conditions, however these cues are predicted to change under future climate projections which may have profound impacts on tree survival and growth.
Here, we use a quantitative genetic approach to estimate the genetic basis of spring and autumn phenology in Populus trichocarpa to determine this species capacity for climate adaptation. We measured bud burst, leaf coloration, and leaf senescence traits across two years (2017-2018) and combine these observations with measures of lifetime growth to determine how genetic correlations between phenology and growth may facilitate or constrain adaptation.
Timing of transitions differed between years, although we found strong cross year genetic correlations in all traits, suggesting that genotypes respond in consistent ways to seasonal cues. Spring and autumn phenology were correlated with lifetime growth, where genotypes that burst leaves early and shed them late had the highest lifetime growth.
We also identified substantial heritable variation in the timing of all phenological transitions (h2 = 0.5-0.8) and in lifetime growth (h2 = 0.8). The combination of additive variation and favourable genetic correlations in phenology traits suggests that populations of cultivated varieties of P. Trichocarpa may have the capability to adapt their phenology to climatic changes without negative impacts on growth.

Gut Microbiota between Environment and Genetic Background in Familial Mediterranean Fever (FMF)

The gastrointestinal tract hosts the natural reservoir of microbiota since birth. The microbiota includes various bacteria that establish a progressively mutual relationship with the host. Of note, the composition of gut microbiota is rather individual-specific and, normally, depends on both the host genotype and environmental factors.
The study of the bacterial profile in the gut demonstrates that dominant and minor phyla are present in the gastrointestinal tract with bacterial density gradually increasing in oro-aboral direction. The cross-talk between bacteria and host within the gut strongly contributes to the host metabolism, to structural and protective functions. Dysbiosis can develop following aging, diseases, inflammatory status, and antibiotic therapy. Growing evidences show a possible link between the microbiota and Familial Mediterranean Fever (FMF), through a shift of the relative abundance in microbial species.
To which extent such perturbations of the microbiota are relevant in driving the phenotypic manifestations of FMF with respect to genetic background, remains to be further investigated.

CHIP Polyclonal Antibody

ES11301-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against CHIP from Human/Mouse. This antibody is tested and validated for WB, ELISA, WB, ELISA

Human CHIP Antibody

32585-05111 150 ug
EUR 261

Anti-CHIP antibody

STJ192459 200 µl
EUR 197
Description: Unconjugated Rabbit polyclonal to CHIP

CHIP Polyclonal Antibody

ABP58142-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

ABP58142-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP Polyclonal Antibody

ABP58142-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of CHIP from Human, Mouse. This CHIP antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human CHIP protein at amino acid sequence of 160-240

CHIP, human recombinant

4898-25
EUR 349

EpiQuik Plant ChIP Kit

P-2014 48 Reactions
EUR 788.05
Description: Ask the seller for details

Polyclonal STUB1 / CHIP Antibody

AMM08034G 0.05ml
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human STUB1 / CHIP . This antibody is tested and proven to work in the following applications:

Anti-STUB1 / CHIP antibody

STJ70128 100 µg
EUR 359

pCMV-HA-chip Plasmid

PVTB00025-2a 2 ug
EUR 356

pcDNA3.0-Flag-CHIP Plasmid

PVTB00152-2b 2 ug
EUR 356

pcDNA3.0-EGFP-CHIP Plasmid

PVTB00152-2c 2 ug
EUR 356

pcDNA3.0-HA-CHIP Plasmid

PVTB00152-2d 2 ug
EUR 356

EpiQuik Chromatin Immunoprecipitation (ChIP) Kit

P-2002 96 Reactions
EUR 904.05
Description: Ask the seller for details

ChromaFlash One-Step ChIP Kit

P-2025 96 reactions
EUR 889.55
Description: fast delivery possible

ChromaFlash High-Sensitivity ChIP Kit

P-2027 48 Reactions
EUR 643.05
Description: Ask the seller for details

Human CHIP Antibody (Biotin Conjugate)

32585-05121 150 ug
EUR 369

Anti-RIP140 Antibody ChIP grade

STJ502791 100 µg
EUR 476

Carboxy Terminus of Hsp70-Interacting Protein (CHIP) Antibody

20-abx142251
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul

Rat E3 ubiquitin protein ligase CHIP ELISA kit

E02E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E3 ubiquitin protein ligase CHIP ELISA kit

E02E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat E3 ubiquitin protein ligase CHIP ELISA kit

E02E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human E3 ubiquitin protein ligase CHIP ELISA kit

E01E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Human E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit E3 ubiquitin protein ligase CHIP ELISA kit

E04E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Rabbit E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse E3 ubiquitin protein ligase CHIP ELISA kit

E03E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Mouse E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig E3 ubiquitin protein ligase CHIP ELISA kit

E07E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Porcine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat E3 ubiquitin protein ligase CHIP ELISA kit

E06E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Goat E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E3 ubiquitin protein ligase CHIP ELISA kit

E08E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Canine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E3 ubiquitin protein ligase CHIP ELISA kit

E08E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Canine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog E3 ubiquitin protein ligase CHIP ELISA kit

E08E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Canine E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey E3 ubiquitin protein ligase CHIP ELISA kit

E09E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Monkey E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

EpiQuik Tissue Chromatin Immunoprecipitation (ChIP) Kit

P-2003 96 Reactions
EUR 904.05
Description: reagents widely cited

EpiQuik Methyl-Histone H3K4 ChIP Kit

P-2007 48 Reactions
EUR 860.55
Description: fast delivery possible

EpiQuik Acetyl-Histone H3 ChIP Kit

P-2010 48 Reactions
EUR 875.05
Description: The best epigenetics products

EpiQuik Acetyl-Histone H4 ChIP Kit

P-2011 48 Reactions
EUR 875.05
Description: kits suitable for this type of research

EpiQuik Methyl-Histone H3K27 ChIP Kit

P-2015 48 Reactions
EUR 889.55
Description: The best epigenetics products

ChromaFlash One-Step Magnetic ChIP Kit

P-2026 96 Reactions
EUR 889.55
Description: reagents widely cited

Pre-Sure ChIP Antibody Validation Kit

P-2031 96 reactions
EUR 1034.55
Description: kits suitable for this type of research

Polyclonal STUB1 / CHIP Antibody (C-Terminus)

AMM08035G 0.05mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human STUB1 / CHIP (C-Terminus). This antibody is tested and proven to work in the following applications:

Human CHIP AssayLite Antibody (FITC Conjugate)

32585-05141 150 ug
EUR 428

Human CHIP AssayLite Antibody (RPE Conjugate)

32585-05151 150 ug
EUR 428

Human CHIP AssayLite Antibody (APC Conjugate)

32585-05161 150 ug
EUR 428

Human CHIP AssayLite Antibody (PerCP Conjugate)

32585-05171 150 ug
EUR 471

Polyclonal Goat Anti-STUB1 / CHIP Antibody

APR16403G 0.1 mg
EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-STUB1 / CHIP . This antibody is tested and proven to work in the following applications:

Anti-Histone H2B - ChIP Grade (4G6)

YF-MA16342 100 ug
EUR 363
Description: Mouse monoclonal to Histone H2B - ChIP Grade

Human E3 ubiquitin-protein ligase CHIP(STUB1) ELISA kit

CSB-EL022887HU-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human E3 ubiquitin-protein ligase CHIP (STUB1) in samples from serum, plasma, tissue homogenates, cell lysates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human E3 ubiquitin-protein ligase CHIP(STUB1) ELISA kit

1-CSB-EL022887HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human E3 ubiquitin-protein ligase CHIP(STUB1) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

EpiQuik Methyl-CpG Binding Domain Protein 2 ChIP Kit

P-2017 48 Reactions
EUR 889.55
Description: fast delivery possible

Human STUB1/ E3 ubiquitin-protein ligase CHIP ELISA Kit

E2420Hu 1 Kit
EUR 571

Human STUB1(E3 ubiquitin-protein ligase CHIP) ELISA Kit

EH3833 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 18.75pg/ml

ELISA kit for Human E3 ubiquitin-protein ligase CHIP

EK4512 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human E3 ubiquitin-protein ligase CHIP in samples from serum, plasma, tissue homogenates and other biological fluids.

Mouse STUB1(E3 ubiquitin-protein ligase CHIP) ELISA Kit

EM1381 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 0.094 ng/ml

Human E3 ubiquitin- protein ligase CHIP, STUB1 ELISA KIT

ELI-50737h 96 Tests
EUR 824

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-192T 192 tests
EUR 1270
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-48 1 plate of 48 wells
EUR 520
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig E3 ubiquitin protein ligase CHIP ELISA kit

E05E0405-96 1 plate of 96 wells
EUR 685
Description: A competitive ELISA for quantitative measurement of Guinea pig E3 ubiquitin protein ligase CHIP in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

EpiQuik Tri-Methyl-Histone H3K9 ChIP Kit

P-2006 48 Reactions
EUR 875.05
Description: kits suitable for this type of research

EpiQuik Tissue Methyl-Histone H3K9 ChIP Kit

P-2008 48 Reactions
EUR 875.05
Description: reagents widely cited

EpiQuik Tissue Methyl-Histone H3K4 ChIP Kit

P-2009 48 Reactions
EUR 875.05
Description: Ask the seller for details

EpiQuik Tissue Acetyl-Histone H3 ChIP Kit

P-2012 48 Reactions
EUR 875.05
Description: fast delivery possible

EpiQuik Tissue Acetyl-Histone H4 ChIP Kit

P-2013 48 Reactions
EUR 875.05
Description: reagents widely cited

EpiQuik Tissue Methyl-Histone H3K27 ChIP Kit

P-2016 48 Reactions
EUR 889.55
Description: kits suitable for this type of research

EpiNext ChIP-Seq High-Sensitivity Kit (Illumina)

P-2030 24 Reactions
EUR 1498.55
Description: The best epigenetics products

ELISA kit for Human STUB1 (E3 ubiquitin-protein ligase CHIP)

E-EL-H5533 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human STUB1 (E3 ubiquitin-protein ligase CHIP) in samples from Serum, Plasma, Cell supernatant

EpiQuik Tissue Methyl-CpG Binding Domain Protein 2 ChIP Kit

P-2018 48 Reactions
EUR 889.55
Description: reagents widely cited

ELISA kit for Human E3 ubiquitin-protein ligase CHIP (STUB1)

KTE60397-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase CHIP (STUB1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human E3 ubiquitin-protein ligase CHIP (STUB1)

KTE60397-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase CHIP (STUB1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human E3 ubiquitin-protein ligase CHIP (STUB1)

KTE60397-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Human E3 ubiquitin-protein ligase CHIP (STUB1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

STUB1 ELISA Kit| Mouse E3 ubiquitin-protein ligase CHIP ELISA Ki

EF013909 96 Tests
EUR 689

Rabbit IgG (non-immune, isotype control, CHIP/IP grade)

20009-1-CH 100 ug
EUR 225

Hyperactive In-Situ ChIP Library Prep Kit for Illumina (pG-Tn5)

TD901-01 12 rxn
EUR 996

Hyperactive In-Situ ChIP Library Prep Kit for Illumina (pG-Tn5)

TD901-02 48 rxn
EUR 3461

Hyperactive In-Situ ChIP Library Prep Kit for Illumina (pA-Tn5)

TD902-01 12 rxn
EUR 996

Hyperactive In-Situ ChIP Library Prep Kit for Illumina (pA-Tn5)

TD902-02 48 rxn
EUR 3461

pLDH Protein Protein

abx061407-1mg 1 mg
EUR 2639

pLDH Protein Protein

abx061408-1mg 1 mg
EUR 2639

Protein A Protein

abx061461-10mg 10 mg
EUR 439

Protein A Protein

abx069907-100mg 100 mg
EUR 467

Protein G Protein

20-abx260044
  • EUR 1970.00
  • EUR 467.00
  • EUR 230.00
  • 100 mg
  • 10 mg
  • 1 mg

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